A study of patients with acute brain injury ( N = 7) is carried out to ascertain the stability of γ. A calibration coefficient (γ) for the CBF is thus determined, permitting conversion of DCS BFI to absolute blood flow units at all other times. Continuous CBF is obtained via calibration of the DCS blood flow index (BFI) with absolute CBF obtained by intermittent intravenous injections of the optical contrast agent indocyanine green. We investigate a scheme for noninvasive continuous monitoring of absolute cerebral blood flow (CBF) in adult human patients based on a combination of time-resolved dynamic contrast-enhanced near-infrared spectroscopy (DCE-NIRS) and diffuse correlation spectroscopy (DCS) with semi-infinite head model of photon propogation. 8 Appendix 3: Computer Simulation to Evaluate CBF Underestimation Using Semi-Infinite Model.7 Appendix 2: Optical Properties Measured with TR-NIRS Based on Semi-infinite Medium.6 Appendix 1: Principle of Customized ICG Dye Densitometer.4.2 CBF Estimates Obtained with Semi-Infinite Head Model Underestimates True CBF.4.1 Estimation of Absolute CBF from DCS BFI Measurements.3.3 Testing Calibrated-DCS for CBF of Brain-Injured Patients in Prior Study.3.2 DCS Calibration across Multiple Days.2.5 Patient Population and Study Design.2.3.2 Instrument response function measurement.2.1.1 Tissue ICG concentration measurement with TR-NIRS.2.1 Dynamic Contrast-Enhanced Time-Resolved Near-Infrared Spectroscopy.

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